for high stakes. Dec 12, 2025 · Gambling is the betting or staking of something of value, with consciousness of risk and hope of gain, on the outcome of a game, a contest, or an uncertain event whose result may be determined by chance or accident or have an unexpected result by reason of the bettor’s miscalculation. Mark won half a million dollars gambling on horses. Gamble definition: To take a risk in the hope of gaining an advantage or a benefit. To play risky games, especially casino games, for monetary gain. See examples of gamble used in a sentence. a venture in a game of chance for stakes, esp. Yesterday, he named his cabinet and took a big gamble in the process. gamble synonyms, gamble pronunciation, gamble translation, English dictionary definition of gamble. to take a chance on; venture; risk: I'm gambling that our new store will be a success.